Our CEO Dr. Thomas Frame featured in the Telegraph


The Royal Academy of Engineering has identified seven of the most promising inventors based in UK universities and is supporting them to turn their research into spin-out companies.

The researchers have been awarded up to £85,000 of funding through the Royal Academy's Enterprise Hub to spend the next 12 months exclusively developing a spin-out business based on their innovations.

Dr Thomas Frame – new cosmetic enhancement system ‘Halo’ promises to reduce wrinkles and fine lines using technology developed for space travel

For the full news story follow this link:


Dr. Thomas Frame of 4SM awarded the Royal Academy of Engineering fellowship worth £85K

Seven UK researchers have been awarded up to £85,000 of funding through the Enterprise Hub to spend the next 12 months exclusively developing a spin-out business based on their innovations. The Hub also provides training and connects each Enterprise Fellow to a mentor from the Academy’s Fellowship, which includes some of the UK’s top technology entrepreneurs. Volunteer mentors include Sir Robin Saxby FREng, Anne Glover CBE HonFREng and Ian Shott CBE FREng.

For the full news story follow this link:


4SM featured in UoS article

One key technology 4SM are investigating is plasma technology. Capable of producing chemicals including nitric oxide and other radicals that can sterilise and deactivate bacteria and heal wounds, the temperature and surface energy delivery of plasma technologies can also be controlled in order to reduce epidermal and superficial dermal thickness.

The team recently created a hand-held plasma device, which can remove the upper layer of dermis and sterilise skin treatment areas. Application of the technology includes wrinkle removal and fine line reductions, treatment of diabetic ulcers and open wounds as well as trauma-related operations like managing acute bleeding.

Dr Tom Frame, founder and CEO of 4SM said, "We have had significant results across a range of histopathology studies and microbiology evaluation, which demonstrates a high level of efficacy across our commercial applications."

For the full news story follow this link:


4SM featured in PMFA NEWS


"Want to do exciting entrepreneurial research? – ask the space scientists"

Advances in medical technology have improved the quality of life for people around the globe and contributed towards a general increase in life expectancy. Much of this can be attributed to a synthesis between the experience of medical professionals and the creativity and ability that biotechnology researchers have in creating precision instrumentation and equipment and to invent or improve techniques..

See more at: PMFA article

Vote for us in the Pitch@Palace People’s Choice Award

Pitch@Palace aims to accelerate and amplify the activities of British Entrepreneurs. The next event will take place on 5th November, 2014 at St. James's Palace. Pitch@Palace was founded by HRH The Duke of York to support entrepreneurs with the amplification and acceleration of their business ideas by connecting them with potential supporters including angels, mentors or key business contacts.

On 20th October 2014, The Duke held Pitch@Palace Bootcamp at Central Working Space, Mile End Road, in partnership with Microsoft Ventures and Wayra. 41 Entrepreneurs, selected by 14 partner organisations, attended workshops, received mentoring and pitched to a panel of judges. 15 teams – one from each partner organisation, as well as an additional wildcard - were then selected to pitch at the live event at St James's Palace on 5th November, 2014. All 41 of the start-ups will also attend the event.

Voting is now live for the P@P People's Choice Award. 4SM offers space age plasma devices for regional cosmetic treatments and advanced wound care without the need for drugs. We are a SETsquaredartnership company! #pitchatpalace #SurreyEngineering


Support and Vote for us in this Pitch@Palace People’s Choice Award here:


Fourth State Medicine Ltd. wins the investment pitch slot at the HRH Duke of York supported event #pitchatpalace

Three SETsquared companies are in with a chance of pitching to HRH Duke of York in a start-up event with a royal twist.

Nu Desine (Bristol), Fourth State Medicine (Surrey) and Smart Antenna Technologies (Bath) have been shortlisted to take part in Pitch@Palace, a project spearheaded by the Duke of York that will culminate in 14 of the UK’s brightest science and technology start ups pitching for investment live in front of hundreds of the biggest names in business at St James’ Palace on November 5.

All three were selected to take part in the first phase of Pitch@Palace, which saw them get investor readiness training, one-to-one business support and pitching advice. They then went through a judging process at a ‘bootcamp’ at Microsoft’s offices yesterday (October 20), after which one lucky company will be selected to pitch their business ideas at the Palace to a room of international investment firms, celebrities and high net worth individuals. The other two members will win an exhibition slot at the event and get the chance to network with guests.

The bootcamp saw a total of 42 businesses pitching their ideas to the panel, and were assessed on three criteria: best pitch, commercial impact and most disruptive idea.

For the full news story follow this link:

Join us for the final event in the Surrey Talks Business series: "The Great Debate: An Evening with Entrepreneurs"

The evening will be led by a panel of 3 entrepreneurs, who will be sharing their business experiences and tips on how to form a successful business, as well as debating the pitfalls and possibilities.

The panel will consist of Charlie Davies from iGeolise, Dr. Tom Frame from Fourth State Medicine Ltd. and Nick Sharples from TorqBak.

To book your ticket and more information please visit this website: