News Blog and Media Coverage


4SM will exhibit at CCR Expo 2016!

Oct. 2016

We will again this year exhibit at CCR Expo 2016! CCR Expo is UK's largest Medical Aesthetic Exhibition. Please contact us to set up meetings with our team!

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4SM will exhibit at MEDICA 2016!

Oct. 2016

We will exhibit at MEDICA 2016! MEDICA is world's leading trade fair for the medical industry. Please contact us to set up meetings with our team!

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4SM Nominated For the IET Innovation Award!

Sept. 2016

We are delighted to be shortlisted with our partner Triteq for the IET's Innovation awards #IETia under the Horizontal Innovation category. The final ceremony will take place on 16 November and the winners will be revealed!

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4SM hosts world leading surgeons from UKAAPS

Feb 2016

We are happy to announce our collaboration with UK Association of Aesthetic Plastic Surgeons (UKAAPS). 4SM will host a special event with 30 world leading aesthetic plastic surgeons with UKAAPS on 5th Feb 2016.

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4SM Present at the BAPRAS Winter Scientific Meeting 2015

Nov 2015

BAPRAS, or more succinctly put the British Association of Plastic Reconstructive & Aesthetic Surgeons is the voice of plastic surgery in the UK and attended by an international audience. 4SM also presented the following article "Translation of Advanced Space Technology to Burns, Trauma and Aesthetic Medicine", Dr. Thomas Frame

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4SM go to CCR and Medica

Oct 2015

 4SM ventured out to the world of cosmetic surgery, looking at everything from competing machines and procedures to consumables and “widgets” to include in our development pathway. The Clinical Cosmetic & Reconstructive (CCR) Expo and MEDICA gave us an amazing platform to showcase our technology, meet potential customers, partners and helped to gauge competition.


4SM Completes its round of funding with assistance from OION

April 2015

Oxford Investment Opportunity Network Ltd (OION) closed its first SEIS Fund with seven companies in the portfolio including 4SM.

Stay tuned for more information and follow this link for more information:


Dr. Thomas Frame of 4SM awarded the Royal Academy of Engineering fellowship worth £85K

2 March 2015

Seven UK researchers have been awarded up to £85,000 of funding through the Enterprise Hub to spend the next 12 months exclusively developing a spin-out business based on their innovations. The Hub also provides training and connects each Enterprise Fellow to a mentor from the Academy’s Fellowship, which includes some of the UK’s top technology entrepreneurs. Volunteer mentors include Sir Robin Saxby FREng, Anne Glover CBE HonFREng and Ian Shott CBE FREng.

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Our CEO Dr. Thomas Frame featured in the Telegraph

4 March 2015

The Royal Academy of Engineering has identified seven of the most promising inventors based in UK universities and is supporting them to turn their research into spin-out companies.

The researchers have been awarded up to £85,000 of funding through the Royal Academy's Enterprise Hub to spend the next 12 months exclusively developing a spin-out business based on their innovations.

Dr Thomas Frame – new cosmetic enhancement system ‘Halo’ promises to reduce wrinkles and fine lines using technology developed for space travel

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4SM featured in the British Airways' Business Life magazine

9 March 2015

It looks like some sort of futuristic ray gun — and it was inspired by space age technology. But in fact the so-called Halo System is a revolutionary cosmetic enhancement tool that utilises plasma (the "fourth state of matter", after solids, liquids and gases) to remove fine lines and wrinkles in the skin.

Halo was developed by a group of scientists based at Surrey University's Space Centre, led by Dr Thomas Frame, who realised that the techniques for using plasma to propel and control satellites in space could be adapted for medical purposes. The input of medical professionals and the expertise of incubation hub SETsquared Surrey subsequently allowed them to put their ideas on a commercial footing in the form of startup Fourth State.

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4SM featured in UoS article

18 February 2015

One key technology 4SM are investigating is plasma technology. Capable of producing chemicals including nitric oxide and other radicals that can sterilise and deactivate bacteria and heal wounds, the temperature and surface energy delivery of plasma technologies can also be controlled in order to reduce epidermal and superficial dermal thickness.

The team recently created a hand-held plasma device, which can remove the upper layer of dermis and sterilise skin treatment areas. Application of the technology includes wrinkle removal and fine line reductions, treatment of diabetic ulcers and open wounds as well as trauma-related operations like managing acute bleeding.

Dr Tom Frame, founder and CEO of 4SM said, "We have had significant results across a range of histopathology studies and microbiology evaluation, which demonstrates a high level of efficacy across our commercial applications."

For the full news story follow this link:


4SM featured in PMFA NEWS

February 2015

"Want to do exciting entrepreneurial research? – ask the space scientists"

Advances in medical technology have improved the quality of life for people around the globe and contributed towards a general increase in life expectancy. Much of this can be attributed to a synthesis between the experience of medical professionals and the creativity and ability that biotechnology researchers have in creating precision instrumentation and equipment and to invent or improve techniques..

See more at: PMFA article


Vote for us in the Pitch@Palace People’s Choice Award

30 October 2014

Pitch@Palace aims to accelerate and amplify the activities of British Entrepreneurs. The next event will take place on 5th November, 2014 at St. James's Palace. Pitch@Palace was founded by HRH The Duke of York to support entrepreneurs with the amplification and acceleration of their business ideas by connecting them with potential supporters including angels, mentors or key business contacts.

On 20th October 2014, The Duke held Pitch@Palace Bootcamp at Central Working Space, Mile End Road, in partnership with Microsoft Ventures and Wayra. 41 Entrepreneurs, selected by 14 partner organisations, attended workshops, received mentoring and pitched to a panel of judges. 15 teams – one from each partner organisation, as well as an additional wildcard - were then selected to pitch at the live event at St James's Palace on 5th November, 2014. All 41 of the start-ups will also attend the event.

Voting is now live for the P@P People's Choice Award. 4SM offers space age plasma devices for regional cosmetic treatments and advanced wound care without the need for drugs. We are a SETsquaredartnership company! #pitchatpalace #SurreyEngineering

Support and Vote for us in this Pitch@Palace People’s Choice Award here: 


Fourth State Medicine Ltd. wins the investment pitch slot at the HRH Duke of York supported event #pitchatpalace

20 October 2014

Three SETsquared companies are in with a chance of pitching to HRH Duke of York in a start-up event with a royal twist.

Nu Desine (Bristol), Fourth State Medicine (Surrey) and Smart Antenna Technologies (Bath) have been shortlisted to take part in Pitch@Palace, a project spearheaded by the Duke of York that will culminate in 14 of the UK’s brightest science and technology start ups pitching for investment live in front of hundreds of the biggest names in business at St James’ Palace on November 5.

All three were selected to take part in the first phase of Pitch@Palace, which saw them get investor readiness training, one-to-one business support and pitching advice. They then went through a judging process at a ‘bootcamp’ at Microsoft’s offices yesterday (October 20), after which one lucky company will be selected to pitch their business ideas at the Palace to a room of international investment firms, celebrities and high net worth individuals. The other two members will win an exhibition slot at the event and get the chance to network with guests.

The bootcamp saw a total of 42 businesses pitching their ideas to the panel, and were assessed on three criteria: best pitch, commercial impact and most disruptive idea.

For the full news story follow this link:


Wayra and Microsoft Ventures support The Duke of York’s vision for growing the UK’s entrepreneurial economy

21 October 2014

Fourth State Medicine Ltd. in Media: "15 start-ups were selected to go forward to the Pitch@Palace final at St James’s Palace on 5 November" #pitchatpalace.

For the full news story follow this link:


Fourth State Medicine Ltd. completes the latest round of #histology evaluation of the new #plasma system, and result show exceptional performance levels!

7 August 2014

We recently completed a successful test campaign with our novel plasma technology and we are happy to report that our recent histology evaluation suggests very promising results. Stay tuned here for further information.


Join us for the final event in the Surrey Talks Business series: "The Great Debate: An Evening with Entrepreneurs"

16 July 2014 

The evening will be led by a panel of 3 entrepreneurs, who will be sharing their business experiences and tips on how to form a successful business, as well as debating the pitfalls and possibilities.

The panel will consist of Charlie Davies from iGeolise, Dr. Tom Frame from Fourth State Medicine Ltd. and Nick Sharples from TorqBak.

To book your ticket and more information please visit this website:  


4SM bags EPSRC Impact Acceleration Award

28 February 2014 

We are happy to announced that we have received Engineering and Physical Sciences Research Council funded University of Surrey's Impact Acceleration award (#IAA) worth £20k. We are excited and looking forward to accelerated development of our advance #PlasmaTech for the medical domain! #Space2Medicine!

For more information about this award please visit this webpage:

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